{"product_id":"biofilm-based-nosocomial-infections-hardcover-2","title":"Biofilm-Based Nosocomial Infections - Hardcover","description":"\u003cdiv\u003e\u003cp style=\"text-align: right;\"\u003e\u003ca href=\"https:\/\/reportcopyrightinfringement.com\/\" target=\"_blank\" rel=\"nofollow\"\u003e\u003cb\u003eReport copyright infringement\u003c\/b\u003e\u003c\/a\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cp\u003eby \u003cb\u003eGianfranco Donelli\u003c\/b\u003e (Guest Editor)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThe well-known persistence in the nosocomial environment of multidrug resistant bacterial\u003cbr\u003e and fungal species, today responsible for a wide variety of healthcare-associated infections, is\u003cbr\u003e believed to be greatly promoted by the ability of most of them to adhere and to grow in sessile\u003cbr\u003e mode on mucosal and soft tissues of hospitalized patients, as well as on the inner and outer\u003cbr\u003e surfaces of indwelling medical devices, including intravenous catheters, orthopaedic, cardiac\u003cbr\u003e valves, intrauterine devices, and contact lenses.\u003cbr\u003e In this regard, a large number of these microorganisms, such as Acinetobacter baumannii, \u003cbr\u003e Candida albicans, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and\u003cbr\u003e Staphylococcus aureus, give rise to highly organized, sessile community defined biofilms, in\u003cbr\u003e which microbes grow encased in a hydrated matrix of extracellular polymeric substances\u003cbr\u003e produced by themselves and are well protected from the attack of antimicrobial molecules and\u003cbr\u003e from the host immune response, by resisting phagocytosis and other body's defense systems.\u003cbr\u003e The great influence of the sessile growth on the effectiveness of the antibiotic therapies is due\u003cbr\u003e to both the structure and function of these microbial communities, making these also 1000\u003cbr\u003e times more tolerant to antibiotics and disinfectants. Thus, alternative approaches to the\u003cbr\u003e common antibiotic treatments are emerging for preventing and treating both the mono-species\u003cbr\u003e and the most frequent multi-species biofilms, including enzymes able to disrupt mature\u003cbr\u003e biofilms and new biomaterials for the coating of medical devices to counteract microbial\u003cbr\u003e adhesion and biofilm formation.\u003cbr\u003e The aim of this Special Issue is to report on the state-of-art of the basic and applied research\u003cbr\u003e in the field of biofilm-based nosocomial infections that can be acquired by patients in both\u003cbr\u003e general hospitals and long-term care settings. Particularly, the involvement of microbial\u003cbr\u003e biofilms in medical device-related infections and other healthcare-associated infections, so far\u003cbr\u003e underestimated and\/or scarcely investigated, has been considered, reviewed, and discussed.\u003c\/p\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 238\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 0.81 x 9.61 x 6.69 IN\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e December 31, 2015\u003c\/div\u003e\n            ","brand":"BooksCloud","offers":[{"title":"Default Title","offer_id":53008770498867,"sku":"9783038421351","price":91.1,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0300\/5595\/6612\/files\/we7pRfU27N9783038421351_907f74fd-9932-4f21-a395-a1462b14a7f6.webp?v=1769677661","url":"https:\/\/www.vysn.com\/products\/biofilm-based-nosocomial-infections-hardcover-2","provider":"VYSN","version":"1.0","type":"link"}