{"product_id":"flavonoids-of-pepper-as-cytokines-inhibitors-paperback","title":"Flavonoids of Pepper as Cytokines Inhibitors - Paperback","description":"\u003cdiv\u003e\u003cp style=\"text-align: right;\"\u003e\u003ca href=\"https:\/\/reportcopyrightinfringement.com\/\" target=\"_blank\" rel=\"nofollow\"\u003e\u003cb\u003eReport copyright infringement\u003c\/b\u003e\u003c\/a\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cp\u003eby \u003cb\u003eAhmed Ezzaldean Abdellah Allam\u003c\/b\u003e (Author)\u003c\/p\u003e\u003cp\u003eVarious naturally occurring phytochemicals exhibit anti-inflammatory activity and are considered to be potential drug candidates against inflammation-related pathological processes. Here, new flavonoid glycoside, kaempferol 3-O-α-¬[(6-P coumaroyl galactopyranosyl-O-β- (1→4)-O-α-rhamnopyranosyl-(1→4)]-O-α-rhamnopyranoside 1, in addition to five known flavonoid glycosides (2-6) kaempferol 3-O-[α- ¬rhamnopyranosyl-(1→4)-O-α-rhamnopyranosyl-(1→6)-O]-β- galactopyranoside (kaempferol 3-O-β-isorhamninoside) 2, quercetin 3-O- [(2,3,4-triacetyl-α-rhamnopyranosyl)-(1→6)-β-galactopyranoside 3, quercetin 3-O-[(2,4-diacetyl-α-rhamnopyranosyl)-(1→6)]-3,4-diacetyl-β- galactopyranoside 4, quercetin 3-O-[(2,4-diacetyl-α-rhamnopyranosyl)- (1→6)]-2,4-diacetyl-β-galactopyranoside 5, quercetin 3-O-[(2,3,4-triacetyl- α-rhamnopyranosyl)-(1→6)-3-acetyl-β-galactopyranoside 6 were isolated from bell pepper (Capsicum annum L.) fruits and tested for both antiinflammatory activity through cytokine production (TNF-α and IL-1β) and antioxidant activity through scavenging effect on 1,1-diphenyl-2- picrylhydrazyl (DPPH) assay. Compounds 1-3 significantly suppressed production of TNF-α \/ IL-1β in cultured THP-1 cells previously costimulated by LPS in a dose-dependent manner (10.2\/49.1, 28.1\/55.7, and 35.2\/57.5 μM respectively) whereas compounds 4-6 have relatively weaker inhibitory activity. (45.3\/73.5, 48.2\/65.6, and 42.2\/67.4 μM respectively). All compounds 1-6 showed no cytotoxic activity against the growth of THP-1where the percentage of cell viability was (127.4, 108.5, 105.4, 103.9, 103.4, and 104.2 μM respectively). All isolated compounds exhibited higher radical scavenging activity than ascorbic acid in (DPPH) assay. These results indicated that bell pepper fruits could be an effective candidate for ameliorating inflammatory-associated complications.\u003c\/p\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 42\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 0.09 x 9 x 6 IN\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e April 30, 2021\u003c\/div\u003e\n            ","brand":"BooksCloud","offers":[{"title":"Default Title","offer_id":53377897890099,"sku":"9781636481821","price":50.88,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0300\/5595\/6612\/files\/ik603TWXWc9781636481821.webp?v=1779330369","url":"https:\/\/www.vysn.com\/en-ca\/products\/flavonoids-of-pepper-as-cytokines-inhibitors-paperback","provider":"VYSN","version":"1.0","type":"link"}